INGREDIENT
sh-Polypeptide-1
Growth Factors
As a fibroblast growth factor, it stimulates keratinocytes and fibroblasts that constitute the skin, promoting skin regeneration and restoring a healthy skin condition. It enhances the proliferation and growth of keratinocytes and activates fibroblasts to boost the synthesis of ECM components such as collagen, fibronectin, and elastin. Through these actions, it helps prevent wrinkles, improves damaged dermal layers, protects and strengthens the skin, and contributes to overall skin renewal by improving both the surface and deeper layers of compromised skin.
sh-Polypeptide-3
Growth Factors
KGF is a key growth factor that stimulates the differentiation, growth, and physiological activity of keratinocytes, which constitute the stratum corneum of the skin. During the wound healing process, KGF promotes the division and epidermalization of skin tissue, enabling complete wound healing. KGF binds to FGF2 receptor 2b (FGFR2b) present on the cell membrane of keratinocytes and stimulates them. KGF interacts with EGF, IGF, and a/bFGF to prevent skin aging and is an essential factor for the healthy recovery of wounded skin.
sh-Polypeptide-11
Growth Factors
Fibroblasts, which biosynthesize key skin components such as collagen, elastin, and hyaluronic acid, are closely linked to skin elasticity and wrinkle formation. aFGF is an essential protein that promotes the proliferation and activation of fibroblasts in the dermal layer of the skin. It also supports the proliferation and activity of keratinocytes, contributing to skin cell regeneration and anti-aging effects.
sh-Oligopeptide-2
Growth Factors
As an insulin-like growth factor, it promotes the regeneration of skin-constituting cells such as fibroblasts and keratinocytes. It also contributes to maintaining the anagen phase by regulating follicular growth. It enhances the expression of ECM-forming proteins, strengthens skin cell function, and provides anti-aging benefits including wrinkle improvement through increased intracellular collagen. Additionally, it promotes angiogenesis in the scalp, improving hair follicles and supporting hair growth.
sh-Polypeptide-64
Growth Factors
Aquaporin (AQP) is a membrane protein that regulates intracellular water transport and is widely expressed in both animals and plants. AQP facilitates the movement of water molecules across the cell membrane through osmotic pressure, allowing water to enter the cell. Multiple AQP channels (1, 3, 5, 7, 9, 10) exist, among which AQP-1 selectively transports water. In skin cells, AQP-1 contributes to hydration and supports improvements in skin barrier function by enhancing intracellular water transport.
sh-Polypeptide-69
Growth Factors
COL3A1 is a protein that promotes the production of type III collagen in the body. Type III collagen is a major fibrous collagen that makes up 5–20% of human tissues. It combines with procollagen and pre-collagen to form the extracellular matrix (ECM), a structural component essential for reinforcing and supporting tissues such as the skin, vascular walls, and various organs. The ECM (Extracellular Matrix) is a non-cellular network composed primarily of collagen and elastin within the skin tissue. It plays a crucial role in maintaining skin elasticity and facilitating cell–cell interactions. When applied to cosmetic or skincare formulations, COL3A1 can promote collagen production in the skin, providing anti-aging benefits such as wrinkle improvement and enhanced firmness.
sh-Polypeptide-73
Growth Factors
CSF-1 (sh-Polypeptide-73) is a bioactive growth factor that plays a key role in skin regeneration and immune modulation. It promotes the proliferation and survival of keratinocytes and fibroblasts, helping maintain healthy skin architecture. By enhancing ECM and collagen production, CSF-1 supports visible improvements in elasticity and wrinkle reduction. CSF-1 also influences the differentiation and activity of various cell types—including myocytes, macrophages, and bone-marrow–derived progenitor cells—strengthening the skin’s natural repair mechanisms. Through these actions, CSF-1 provides anti-aging, anti-wrinkle, and wound-healing benefits, making it highly effective for restoring weakened or aging skin barriers.
sh-Polypeptide-10
Growth Factors
KGF is a key growth factor that stimulates the differentiation, growth, and physiological activity of keratinocytes, which constitute the stratum corneum of the skin. During the wound healing process, KGF promotes the division and epidermalization of skin tissue, enabling complete wound healing. KGF binds to FGF2 receptor 2b (FGFR2b) present on the cell membrane of keratinocytes and stimulates them. KGF interacts with EGF, IGF, and a/bFGF to prevent skin aging and is an essential factor for the healthy recovery of wounded skin.
sh-Polypeptide-31
Growth Factors
As an insulin-like growth factor, it promotes the regeneration of skin-constituting cells such as fibroblasts and keratinocytes. It also contributes to maintaining the anagen phase by regulating follicular growth. It enhances the expression of ECM-forming proteins, strengthens skin cell function, and provides anti-aging benefits including wrinkle improvement through increased intracellular collagen. Additionally, it promotes angiogenesis in the scalp, improving hair follicles and supporting hair growth.
sh-Oligopeptide-14
Growth Factors
Rantes is a protein ingredient that promotes keratinocyte and fibroblast proliferation, supporting skin regeneration and improved elasticity. It enhances ECM production and collagen synthesis, offering benefits for wrinkle reduction and wound healing, while also helping regulate immune cell recruitment to inflammatory sites. Composed of highly purified sh-Oligopeptide-14, it delivers effective anti-aging and skin-improving functions.
sh-Polypeptide-72
Growth Factors
EPO is a protein ingredient that promotes keratinocyte and fibroblast proliferation, supporting skin regeneration and improved firmness. It enhances ECM and collagen synthesis to reduce wrinkles and accelerates wound healing for healthier skin recovery. EPO also contributes to erythroid cell differentiation and vitality, helping boost overall skin radiance. This highly purified sh-Polypeptide-72 offers effective anti-aging and skin-improving benefits.
sh-Polypeptide-26
Growth Factors
Flt-3L is a growth factor–based protein ingredient that promotes keratinocyte and fibroblast activity to support skin regeneration and firmness. It increases ECM and collagen production for effective wrinkle improvement and contributes to enhanced wound recovery. Flt-3L also acts on hematopoietic progenitor cells, helping strengthen skin immunity and overall vitality as a highly purified sh-Polypeptide-26 ingredient.
sh-Oligopeptide-16
Growth Factors
Fractalkine is a functional protein-derived ingredient that enhances keratinocyte and fibroblast activity to support skin regeneration and firmness. It boosts ECM and collagen production for improved wrinkle reduction and structural resilience, while also aiding in wound recovery. Formulated with highly purified sh-Oligopeptide-16, it serves as a premium peptide ingredient for advanced anti-aging applications.
sh-Oligopeptide-33
Growth Factors
hBD3H is a functional peptide ingredient with broad and potent antimicrobial activity against skin disease–related microorganisms. It effectively reduces harmful bacteria such as Staphylococcus aureus and Propionibacterium acnes, supporting improvements in acne and atopic dermatitis. hBD3H also targets microorganisms associated with dandruff, providing scalp-care benefits as a highly purified sh-Oligopeptide-33.
sh-Polypeptide-62
Growth Factors
HGF is a growth factor protein that enhances cell motility and regeneration, helping improve scalp health, prevent hair loss, and promote hair growth. It supports collagen synthesis for improved skin and scalp elasticity, while aiding epidermal repair for healthier overall skin condition. Formulated with highly purified sh-Polypeptide-62, HGF serves as a premium ingredient for advanced hair and skin care applications.
sh-Polypeptide-7
Growth Factors
hGH is a growth hormone–derived ingredient that enhances epidermal cell proliferation and regeneration, supporting improved skin firmness and wrinkle reduction. It promotes collagen synthesis for stronger skin structure and aids epidermal repair while contributing to hair growth benefits. Formulated with highly purified sh-Polypeptide-7, it serves as a premium ingredient for anti-aging and hair care applications.
sh-Polypeptide-81
Growth Factors
HSP70 is a functional protein ingredient that enhances cellular stress resistance and supports the recovery of damaged skin tissues. It promotes keratinocyte and fibroblast activity to improve skin regeneration and firmness, while boosting ECM and collagen synthesis for wrinkle reduction. With protective effects against thermal and oxidative stress and the ability to inhibit apoptosis, HSP70 serves as a highly purified sh-Polypeptide-81 anti-aging ingredient.
sh-Polypeptide-81
Growth Factors
IFN-γ is an immunomodulatory protein ingredient that enhances skin cell activation, supporting regeneration and improved elasticity. It boosts ECM and collagen synthesis for wrinkle reduction, while strengthening immune defense against viral and certain bacterial challenges. With additional immunostimulatory benefits that can support scalp health and hair growth, IFN-γ serves as a highly purified sh-Polypeptide-38 functional ingredient.
sh-Polypeptide-18
Growth Factors
IL-1β is a cytokine-based protein ingredient that regulates skin cell activity to support regeneration and improved firmness. It promotes keratinocyte and fibroblast proliferation, enhancing ECM and collagen production while contributing to skin tone improvement and reduced pigmentation. This highly purified sh-Polypeptide-18 also supports scalp health and hair growth benefits.
sh-Polypeptide-25
Growth Factors
IL-2 is a cytokine-based protein ingredient that plays a key role in immune regulation, supporting balanced skin immunity and tissue recovery. It regulates T-cell differentiation and proliferation, contributing to enhanced skin defense and wound healing processes. Formulated with highly purified sh-Polypeptide-25, IL-2 is a functional ingredient for immune-supporting and anti-aging skincare applications.
sh-Polypeptide-43
Growth Factors
IL-6 is a cytokine-based protein ingredient that promotes skin cell proliferation and survival, supporting skin regeneration and recovery. It enhances ECM and collagen production through keratinocyte and fibroblast activation, contributing to improved elasticity and wrinkle reduction. With additional immune-enhancing properties, IL-6 helps protect the skin from external stressors as a highly purified sh-Polypeptide-43.
sh-Oligopeptide-72
Growth Factors
IL-8 is a cytokine-based protein ingredient that promotes skin cell proliferation and survival, supporting skin regeneration and recovery. It enhances ECM and collagen production via keratinocyte and fibroblast activation, contributing to improved elasticity and wrinkle reduction. With immune-enhancing properties, IL-8 helps strengthen skin defense as a highly purified sh-Oligopeptide-72 ingredient.
sh-Polypeptide-6
Growth Factors
L-10 is a cytokine-based protein ingredient that helps regulate skin immune balance, calming sensitive skin and supporting recovery. It modulates immune responses to reduce irritation while contributing to wound healing and improved regenerative conditions. Formulated with highly purified sh-Polypeptide-6, IL-10 is a functional ingredient for immune-regulating and skin-repair applications.
sh-Polypeptide-14
Growth Factors
NGF is a nerve growth factor–based protein ingredient that regulates cellular activity in the skin and scalp, supporting regeneration and recovery. It promotes epidermal cell proliferation and enhances collagen and elastin synthesis, contributing to improved skin elasticity and wrinkle reduction. NGF also helps improve the hair follicle environment to support hair growth as a highly purified rh-Polypeptide-14 ingredient.
sh-Polypeptide-13
Growth Factors
Noggin is a functional growth factor protein that inhibits BMP signaling, playing a critical role in hair follicle development and hair growth. It helps increase hair follicle numbers and promotes the transition of hair follicles into the growth phase, supporting hair regeneration and reduced hair loss. Formulated with highly purified sh-Polypeptide-13, Noggin is an effective ingredient for advanced hair care applications.
sh-Polypeptide-9
Growth Factors
Promotes blood vessel development to ensure optimal nutrient supply to skin and hair follicles, while stimulating collagen synthesis and epidermal cell growth for anti-aging and wound healing. It significantly helps prevent hair loss and encourages hair growth by stimulating follicular formation.
sh-Polypeptide-2
Growth Factors
Protects cells from free radicals with strong anti-oxidant properties, increasing cellular lifespan and preventing skin aging. It stimulates collagen synthesis and cell proliferation for wound recovery, and acts as a multi-functional ingredient that prevents hair loss and promotes hair growth by rejuvenating injured hair follicle cells.
sh-Polypeptide-8
Growth Factors
PDGF-A is a growth factor protein that stimulates cell proliferation and tissue regeneration, playing a key role in wound healing and skin recovery. It promotes collagen synthesis for wrinkle improvement and skin firmness, while also supporting hair follicle formation to enhance hair growth and reduce hair loss. PDGF-A is formulated with highly purified sh-Polypeptide-8 for multifunctional skin and hair care applications.
sh-Polypeptide-59
Growth Factors
PDGF-B is a growth factor that promotes fibroblast and dermal papilla cell proliferation, making it especially effective for skin regeneration and hair growth. It plays an important role in tissue repair and wound healing, while improving scalp conditions to strengthen the foundation for healthy hair growth. PDGF-B is formulated with highly purified sh-Polypeptide-59 for advanced skin and hair repair applications.
sh-Polypeptide-33
Growth Factors
Stimulates the proliferation of keratinocytes and fibroblasts, inducing ECM and collagen synthesis to improve skin elasticity and reduce wrinkles. Acts as a signaling protein to regulate immune cells, while protecting against hair loss and promoting hair growth by rejuvenating injured hair follicle cells.
sh-Oligopeptide-4
Growth Factors
Increases the number of hair follicles and stimulates cell proliferation, migration, and differentiation to strongly induce hair growth and regeneration. It is a specialized ingredient that prevents hair loss and helps maintain healthy hair.
sh-Polypeptide-22
Growth Factors
Stimulates epidermal cell growth specifically for wound healing and induces collagen synthesis to aid in wrinkle recovery and skin regeneration. It promotes hair growth by stimulating hair follicle formation and offers multi-functional benefits including anti-aging and whitening effects.
sh-Polypeptide-5
Growth Factors
Stimulates epidermal cell growth specifically for wound healing and induces collagen synthesis to aid in wrinkle recovery and skin regeneration. It promotes hair growth by stimulating hair follicle formation and offers multi-functional benefits including anti-aging and whitening effects.
sh-Polypeptide-19
Growth Factors
Stimulates the proliferation of keratinocytes and fibroblasts, inducing collagen and ECM synthesis for skin regeneration and elasticity. It induces epithelial development and prevents hair loss while promoting hair growth by rejuvenating injured hair follicle cells.
sh-Polypeptide-58
Growth Factors
Acts as the most powerful cellular protector in skin tissue regeneration and acts as a natural inhibitor of matrix metalloproteinases (MMPs) to prevent collagen degradation. It stimulates fibroblast proliferation and rejuvenates injured hair follicle cells, contributing to hair loss prevention.
sh-Polypeptide-16
Growth Factors
PGF is a growth factor that stimulates epidermal cell growth, proliferation, and differentiation, playing an important role in skin regeneration and wound healing. It enhances collagen synthesis to help reduce wrinkle formation and supports recovery of damaged epidermal tissue. PGF is formulated with highly purified sh-Polypeptide-16 for advanced skin repair and regeneration applications.
sh-Polypeptide-4
Growth Factors
SCF is a growth factor that activates stem cells and promotes tissue regeneration, playing a key role in skin repair and wound healing. It protects cells from free radical damage and enhances cellular survival, supporting recovery of damaged skin and hair follicles. Formulated with highly purified sh-Polypeptide-4, SCF is suitable for advanced skin and scalp repair applications.
sh-Polypeptide-66
Growth Factors
SIRT-1 is a sirtuin protein that regulates cellular survival and stress resistance, playing a key role in skin anti-aging and regeneration. It promotes keratinocyte and fibroblast proliferation while enhancing ECM production to support wrinkle improvement and skin recovery. SIRT-1 helps maintain healthy skin conditions under external stress as a highly purified sh-Polypeptide-66 ingredient.
sh-Polypeptide-67
Growth Factors
SIRT-2 is a sirtuin protein involved in cellular homeostasis and stress response, contributing to skin regeneration and damage recovery. It supports keratinocyte and fibroblast survival while promoting ECM production to help stabilize skin structure. SIRT-2 is formulated with sh-Polypeptide-67 to support skin recovery under environmental stress conditions.
sh-Polypeptide-60
Growth Factors
SOD-1 is an antioxidant enzyme that neutralizes reactive oxygen species, protecting skin cells from oxidative stress associated with skin aging. It helps reduce free radical damage and enhances cellular survival, supporting skin protection and recovery. Formulated with sh-Polypeptide-60, SOD-1 is suitable for antioxidant skin and scalp care applications.
sh-Polypeptide-51
Growth Factors
SOD-3 is an extracellular antioxidant enzyme that scavenges reactive oxygen species, helping protect skin tissue from oxidative damage. It reduces free radical-induced skin damage and supports the collagen environment to maintain skin elasticity. SOD-3 is formulated with sh-Polypeptide-51 for antioxidant protection and skin recovery applications.
sh-Oligopeptide-1
Growth Factors
EGF, also known as “Epidermal Growth Factor” or “Cell Regeneration Factor,” is a naturally occurring molecule in the human body. It binds to EGF receptors on the surface of the skin and promotes the production of new skin cells. EGF was discovered by American biologist Dr. Stanley Cohen, who was awarded the Nobel Prize in Physiology or Medicine for this breakthrough. In the context of skincare and cosmetics, EGF promotes skin cell regeneration and stimulates fibroblasts within the skin to boost elastin and collagen synthesis, making it effective for improving skin elasticity and reducing wrinkles.
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